Determinants of Cell-to-Cell Variability in Protein Kinase Signaling
نویسندگان
چکیده
منابع مشابه
Determinants of Cell-to-Cell Variability in Protein Kinase Signaling
Cells reliably sense environmental changes despite internal and external fluctuations, but the mechanisms underlying robustness remain unclear. We analyzed how fluctuations in signaling protein concentrations give rise to cell-to-cell variability in protein kinase signaling using analytical theory and numerical simulations. We characterized the dose-response behavior of signaling cascades by ca...
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ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2013
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1003357